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The Harold Varmus Papers

Title:
[Revertant DNA data] (image 2)
(normal size jpg)

(high resolution jpg) High resolution version (8,135,867 Bytes)

Description:
Varmus made extensive use of gel electrophoresis in his study of the genetics of retroviruses, namely to determine the quantity and structure of viral DNA prepared from extracts from the nucleus and cytoplasm (the substance surrounding the nucleus) of cells infected with Avian Sarcoma Virus (ASV). The technology enabled Varmus, for example, to show the existence of proviruses of ASV, the double-stranded DNA version of the double-stranded RNA of which the ASV genome is made. By forming a provirus, retroviruses are able to integrate themselves into the DNA of host cells.
The lanes shown in this figure were formed when electrically charged (ionic) DNA fragments, which had been dissolved in a solvent and spread on an agarose gel as a support medium, migrate across an electric field and are separated according to the speed of their migration as well as according to changes they undergo during their migration.
Number of Image Pages:
1 (151,199 Bytes)
Date Supplied:
1978-1979
Creator:
[Varmus, Harold]
Source:
Original Repository: University of California, San Francisco. Archives and Special Collections. Harold E. Varmus Papers
Rights:
Reproduced with permission of the Regents of the University of California.
Subject:
Medical Subject Headings (MeSH):
DNA
Exhibit Category:
Retroviruses and the Genetic Origins of Cancer, 1970-1993
Relation:
Metadata Record [Revertant DNA data] (image 1) [1978-1979] jpg (268,057 Bytes)
/ps/access/MVBBHP_.jpg
Metadata Record [Revertant DNA data] (image 3) [1978-1979] jpg (182,435 Bytes)
/ps/access/MVBBHR_.jpg
Box Number: 6
Folder Number: 16
Unique Identifier:
MVBBHQ
Document Type:
Photographic prints
Format:
image/jpeg
image/tif
Physical Condition:
Good
Series: UCSF Collections
SubSeries: Collection Number MSS 84-25
SubSubSeries: Research, 1970-1984
Folder: Illustrations, 1978-1979
Metadata Last Modified Date:
2006-10-18
Linked Data:
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