The Harold Varmus Papers
- Annealing cDNA3' and cDNA5' to Linear ASV DNA
High resolution version (2,589,159 Bytes)
- In 1976, Harold Varmus and Michael Bishop reported their pathbreaking discovery that a nucleotide sequence--the four letters
of the DNA alphabet--of single-stranded, radioactive DNA from the normal cells of various species of birds (cDNA) could "anneal,"
or associate, with the cancer-causing gene, or oncogene, in Avian sarcoma virus (ASV) to form a double-stranded molecule.
Their discovery suggested that normal, non-cancerous cells contain genes--proto-oncogenes, as Varmus and Bishop called them--that
might mutate and cause cancer. The ultimate cause of cancer, the two scientists suggested, was to be found within our own
genes. This slide provided a schematic of the annealing process.
- Number of Image Pages:
- 1 (171,490 Bytes)
- Date Supplied:
- [University of California, San Francisco]
- Original Repository: University of California, San Francisco. Archives and Special Collections. Harold E. Varmus Papers
- Reproduced with permission of the Regents of the University of California.
- Medical Subject Headings (MeSH):
- Avian Sarcoma Viruses
- Exhibit Category:
- Retroviruses and the Genetic Origins of Cancer, 1970-1993
- Box Number: 7
- Folder Number: 5
- Unique Identifier:
- Document Type:
- Slides (photographs)
- Charts (graphic documents)
- Physical Condition:
- Series: UCSF Collections
- SubSeries: Collection Number MSS 84-25
- SubSubSeries: Research, 1970-1984
- Folder: Slides from Binder - Avian DNA, viral DNA, sarc, 1978-1979
- Metadata Last Modified Date:
- Linked Data: