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The Louis Sokoloff Papers

Title:
Brain Glucose Utilization in Mice with a Targeted Mutation in the Thyroid Hormone alpha or beta Receptor Gene pdf (1,250,007 Bytes) ocr (32,548 Bytes)
Brain Glucose Utilization in Mice with a Targeted Mutation in the Thyroid Hormone alpha or beta Receptor Gene
Description:
The study demonstrated that in mice a targeted mutation of the TRα thyroid hormone receptor that prevents it from binding thyroid hormone results in the same retardation of body growth and maturation of local cerebral glucose utilization as seen in cretinism produced by neonatal thyroidectomy whereas a corresplnding mutation in the TRβ thyroid hormone receptor has no such effects. This study demonstrates that thyroid binding to the TRα thyroid hormone receptor and not at all to the TRβ receptor is critical to the normal maturation of the brrain.
Number of Image Pages:
6 (1,250,007 Bytes)
Date:
2001-08-14 (August 14, 2001)
Creator:
Itoh, Yoshiaki
Esaki, Takanori
Kaneshige, Masahiro
Suzuki, Hideyo
Cook, Michelle
Sokoloff, Louis
Cheng, Sheue-Yann
Nunez, Jacques
National Institute of Mental Health (U.S.)
National Cancer Institute (U.S.)
Source:
Periodical: Itoh, Yoshiaki, Takanori Esaki, Masahiro Kaneshige, Hideyo Suzuki, Michelle Cook, Louis Sokoloff, Sheue-Yann Cheng, Jacques Nunez, National Institute of Mental Health (U.S.), and National Cancer Institute (U.S.). "Brain Glucose Utilization in Mice with a Targeted Mutation in the Thyroid Hormone alpha or beta Receptor Gene." Proceedings of the National Academy of Sciences of the United States of America 98, 17 (14 August 2001): 9913-9918. Article. 6 Images.
Publisher:
National Academy of Sciences (U.S.)
Rights:
This item is in the public domain. It may be used without permission.
Subject:
Medical Subject Headings (MeSH):
Brain
Glucose
Mutation
Thyroid Hormones
Exhibit Category:
Positron Emission Tomography Scanning and Beyond, 1979-2004
Box Number: 40
Folder Number: 18
Unique Identifier:
NLBBFB
Document Type:
Articles
Language:
English
Format:
application/pdf
image/tif
Physical Condition:
Good
Metadata Last Modified Date:
2016-08-15
Linked Data:
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