Brain Glucose Utilization in Mice with a Targeted Mutation in the Thyroid Hormone alpha or beta Receptor Gene
The study demonstrated that in mice a targeted mutation of the TRα thyroid hormone receptor that prevents it from binding
thyroid hormone results in the same retardation of body growth and maturation of local cerebral glucose utilization as seen
in cretinism produced by neonatal thyroidectomy whereas a corresplnding mutation in the TRβ thyroid hormone receptor
has no such effects. This study demonstrates that thyroid binding to the TRα thyroid hormone receptor and not at all
to the TRβ receptor is critical to the normal maturation of the brrain.
Number of Image Pages:
6 (1,250,007 Bytes)
2001-08-14 (August 14, 2001)
National Institute of Mental Health (U.S.)
National Cancer Institute (U.S.)
Periodical: Itoh, Yoshiaki, Takanori Esaki, Masahiro Kaneshige, Hideyo Suzuki, Michelle Cook, Louis Sokoloff, Sheue-Yann Cheng, Jacques
Nunez, National Institute of Mental Health (U.S.), and National Cancer Institute (U.S.). "Brain Glucose Utilization in
Mice with a Targeted Mutation in the Thyroid Hormone alpha or beta Receptor Gene." Proceedings of the National Academy
of Sciences of the United States of America 98, 17 (14 August 2001): 9913-9918. Article. 6 Images.
National Academy of Sciences (U.S.)
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Medical Subject Headings (MeSH):
Positron Emission Tomography Scanning and Beyond, 1979-2004