Sokoloff responded to Mori's letter of 26 October 1992, with detailed explanations of the glucose studies equations.
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1992-11-10 (November 10, 1992)
National Institute of Mental Health (U.S.)
Juntendo University School of Medicine
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Positron Emission Tomography Scanning and Beyond, 1979-2004
Letter from Louis Sokoloff to Kentaro Mori (January 14, 1993)
Letter from Kentaro Mori to Louis Sokoloff (December 13, 1992)
Letter from Kentaro Mori to Louis Sokoloff (October 26, 1992)
Box Number: 1
Folder Number: 52
November 10, 1992
Sorry to be so late in replying to your urgent letter, but I was away at the Society of Neuroscience meeting in Anaheim, California
and am just now trying to catch up.
I am enclosing a rewritten version of the 3 equations about which you had questions. I believe that they are correct. As for
your questions, my answers are as follows:
1) You will have to measure the [lambda]MG (i.e. equilibrium tissue:plasma distribution ratios for methylglucose) at various
plasma glucose concentrations in the steady state. You know how to do this because you already have while you were here. The
[lambda]IAP should not change with plasma glucose concentration except possibly when the changes in plasma glucose concentration
are so severe that they might shrink or swell the brain because of osmotic effects.
2) K(T-MG) is a property of the glucose transporter. Since there is only one known transporter for glucose across the blood-brain
barrier (i.e., GLUT-1), there should only be one K(T-MG) everywhere in the brain and we have no reason to believe that it
would change in pathology unless the blood-brain barrier is broken.
The news about our current budget and especially our travel funds is not good. We are being cut severely, and I don't
know what this might mean to our travel to the Brain '93 meeting in Sendai. It is possible that none of us will be able
to get the travel support from NIH to go. We will keep you informed.