Skip to main contentU.S. National Library of MedicineU.S. National Library of Medicine

Profiles in Science
Pinterest badge Follow Profiles in Science on Pinterest!

The Louis Sokoloff Papers

Letter from Louis Sokoloff to Kentaro Mori pdf (74,357 Bytes) transcript of pdf
Letter from Louis Sokoloff to Kentaro Mori
Sokoloff responded to Mori's letter of 26 October 1992, with detailed explanations of the glucose studies equations.
Item is a photocopy.
Number of Image Pages:
2 (74,357 Bytes)
1992-11-10 (November 10, 1992)
Sokoloff, Louis
National Institute of Mental Health (U.S.)
Mori, Kentaro
Juntendo University School of Medicine
This item is in the public domain. It may be used without permission.
Exhibit Category:
Positron Emission Tomography Scanning and Beyond, 1979-2004
Metadata Record Letter from Louis Sokoloff to Kentaro Mori (January 14, 1993) pdf (57,063 Bytes) transcript of pdf
Metadata Record Letter from Kentaro Mori to Louis Sokoloff (December 13, 1992) pdf (54,381 Bytes) transcript of pdf
Metadata Record Letter from Kentaro Mori to Louis Sokoloff (October 26, 1992) pdf (69,316 Bytes) transcript of pdf
Box Number: 1
Folder Number: 52
Unique Identifier:
Document Type:
Letters (correspondence)
Physical Condition:
November 10, 1992
Dear Ken:
Sorry to be so late in replying to your urgent letter, but I was away at the Society of Neuroscience meeting in Anaheim, California and am just now trying to catch up.
I am enclosing a rewritten version of the 3 equations about which you had questions. I believe that they are correct. As for your questions, my answers are as follows:
1) You will have to measure the [lambda]MG (i.e. equilibrium tissue:plasma distribution ratios for methylglucose) at various plasma glucose concentrations in the steady state. You know how to do this because you already have while you were here. The [lambda]IAP should not change with plasma glucose concentration except possibly when the changes in plasma glucose concentration are so severe that they might shrink or swell the brain because of osmotic effects.
2) K(T-MG) is a property of the glucose transporter. Since there is only one known transporter for glucose across the blood-brain barrier (i.e., GLUT-1), there should only be one K(T-MG) everywhere in the brain and we have no reason to believe that it would change in pathology unless the blood-brain barrier is broken.
The news about our current budget and especially our travel funds is not good. We are being cut severely, and I don't know what this might mean to our travel to the Brain '93 meeting in Sendai. It is possible that none of us will be able to get the travel support from NIH to go. We will keep you informed.
Sincerely yours,
Louis Sokoloff
Metadata Last Modified Date:
Linked Data:
RDF/XML     JSON     JSON-LD     N3/Turtle     N-Triples