Positron Emission Tomography Scanning and Beyond, 1979-2004
Letter from Louis Sokoloff to Kentaro Mori (January 14, 1993)
Letter from Kentaro Mori to Louis Sokoloff (December 13, 1992)
Letter from Louis Sokoloff to Kentaro Mori (November 10, 1992)
Box Number: 1
Folder Number: 52
Oct. 26, 1992
Dear Dr. Sokoloff
I was very glad to see you again at NIH. I enjoyed your clear lectures very much. Since I returned to Japan, I have been looking
for laboratory for Radio-isotope use because in my hospital we are prohibited from using RI for animals. But, I will love
this problem soon.
I am always thinking about the equation to get Vm* and KT*. You gave me an equation to solve Vm* and KT* for methyl glucose
I have several question about equation.
Q1. To get Vm* and KT*. We need PS* values at different plasma glucose concentration. To get diffusion limitation of methyl
glucose (m MG), we also need information about [lambda]MG and [lambda]IAP according to [Equation #1]. I know [lambda]MG is
different at different plasma glucose concentration. How about [lambda]IAP? Is it different at different plasma glucose concentration?
Do I need data of [lambda]IAP at different plasma glucose concentrations by different animal group?
Q2. [Equation #2] is final equation to get Vm* and KT*. I know KT for glucose is about 6.8. However, is KT same value at different
plasma glucose concentration and different brain structures?
In pathological condition, I think KT should change. So, according to [Equation #3], it is impossible to get Vm* and KT* without
information of KT. What do you think about that?
I know you are extremely busy person. But, could you answer my questions?
I am looking forward to seeing in Sendai next year. I will attend reunion party in Sendai.