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The Louis Sokoloff Papers

Effect of L-DOPA treatment on brain metabolism in the monkey
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Sokoloff's group used the deoxyglucose method to study many brain phenomena, including the effects of various drugs on cerebral metabolism. A series of studies in the mid-1980s explored the effects of l-dopa in the brains of monkeys with parkinsonism induced by MPTP. This is one of the slides used for presentations. It's a color-coded autoradiograph of a coronal section. It shows clearly that l-dopa increases metabolism in the brains of monkeys with induced parkinsonism, though not much in normal brains. See, e.g., LG Porrino, et al., "Changes in local cerebral glucose utilization associated with Parkinson's syndrome induced by 1-methyl-phenyl-1,2,3,6-tetrohydropyridine (MPTP) in the primate," Life Sciences 40 (1987): 1657-1664.
Number of Image Pages:
1 (235,335 Bytes)
Date Supplied:
ca. 1985
National Institute of Mental Health (U.S.)
This item is in the public domain. It may be used without permission.
Exhibit Category:
Positron Emission Tomography Scanning and Beyond, 1979-2004
Box Number: 141
Folder Number: 10
Unique Identifier:
Document Type:
Slides (photographs)
Physical Condition:
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