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The Louis Sokoloff Papers

EMail from Louis Sokoloff to Amir H. Assadi pdf (66,404 Bytes) transcript of pdf
EMail from Louis Sokoloff to Amir H. Assadi
These emails are part of an exchange between Assadi, a mathematician interested in imaging algorithms, and Sokoloff, regarding the possibility of Assadi doing some work in a neuroscience imaging lab. Sokoloff commented on the lack of scientific rigor in recent studies using functional MRI scanning.
Item is a photocopy.
Number of Image Pages:
1 (66,404 Bytes)
1999-11-08 (November 8, 1999)
Sokoloff, Louis
National Institute of Mental Health (U.S.)
Assadi, Amir H.
University of Wisconsin
This item is in the public domain. It may be used without permission.
Exhibit Category:
Positron Emission Tomography Scanning and Beyond, 1979-2004
Metadata Record EMail from Amir H. Assadi to Louis Sokoloff (March 9, 2000) pdf (153,480 Bytes) transcript of pdf
Metadata Record EMail from Louis Sokoloff to Amir H. Assadi [ca. March 2000] pdf (103,013 Bytes) transcript of pdf
Box Number: 1
Folder Number: 5
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Document Type:
Electronic mail
Physical Condition:
November 8, 1999
Dear Amir:
Sorry to hear about your health problems and that you will not be able to visit us as planned. There are now so many effective pharmacological agents intervening at different levels that I thought was no longer a major medical problem. I know of a number of people, myself included, in which is completely under control with a variety of drugs. I hope the same will be true with you also.
Your description of your interest and some of your ideas has indicated to me that we do have much to talk about and that we will be able to reschedule your visit soon. December is not a good time for me because I have to be in Germany during the first 2 weeks and then have some commitments after my return. The week of January 9 is entirely open.
Your comments on fMRI are entirely in accord with ours. We share the same reservations. Although our Laboratory pioneered the use of functional brain mapping on the basis of changes in energy metabolism and/or blood flow, we are embarrassed at how the field is being abused by descriptive methods that produce signals the relationship of which to some physiological function is still obscure. I am a firm believer in Lord Kelvin's statement, "If you cannot describe it in numbers, your knowledge is of a meager and unsatisfactory kind," but currently in the field of functional brain imaging, there appears to be little appreciation of quantitative measurements of defined physiological processes. All they care about is where in the brain they find a colored spot and not why. Maybe this is because the field is now so heavily invaded by psychologists rather than real scientists. In any case, we still adhere to model development and evaluation, and I believe that we do have things to discuss.
In the meantime, we are sending out today the reprints that you requested. If you are interested in any others, please let us know.
Best regards and best wishes for a speedy recovery.
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