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The Daniel Nathans Papers

Letter from Daniel Nathans to Ernest Winocour pdf (62,756 Bytes) transcript of pdf
Letter from Daniel Nathans to Ernest Winocour
Number of Image Pages:
1 (62,756 Bytes)
1971-12-01 (December 1, 1971)
Nathans, Daniel
Winocour, Ernest
Weizmann Institute of Science
Original Repository: Alan Mason Chesney Medical Archives. Daniel Nathans Collection
Reproduced with permission of Joanne Nathans.
Medical Subject Headings (MeSH):
Haemophilus influenzae
Exhibit Category:
Restriction Enzymes and the "New Genetics," 1970-1980
Unique Identifier:
Document Type:
Letters (correspondence)
Physical Condition:
December 1, 1971
Dear Ernest:
Your paper on the presence of cellular DNA in the DNA of defective SV40 virions is very interesting. I would be happy to help in the experiments with DNA fragments which you outlined. We have looked at the H. influenzae restriction enzyme cleavage of DNA from light defective particles, and the digest contains all the pieces seen with DNA from normal particles plus others. I am not yet content with these experiments and have just prepared another batch of labelled DNA from defectives to repeat the digestion and electrophoresis.
Kathleen Danna is sending you a culture of H. influenzae and directions for growing it. We have been told by Roger Herriott, from whom this strain was obtained, that it is nonpathogenic. We shall have a large batch of enzyme shortly and can send you some of it, if it can be shipped in ice. However, preparation of the enzyme is not difficult using the Smith and Wilcox assay.
I have the feeling that attempting to collaborate might be troublesome, although I would enjoy the association. Let's do whatever is necessary to get the work done and if our part turns out to be minor, there is no need to consider the project a collaborative one.
With my best regards to you and to Maxine,
Daniel Nathans
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