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The Daniel Nathans Papers

Title:
Letter from Daniel Nathans to Antonio M. Persico pdf (52,206 Bytes) transcript of pdf
Letter from Daniel Nathans to Antonio M. Persico
Number of Image Pages:
1 (52,206 Bytes)
Date:
1992-01-15 (January 15, 1992)
Creator:
Nathans, Daniel
Recipient:
Persico, Antonio M.
[National Institute on Drug Abuse]
Source:
Original Repository: Alan Mason Chesney Medical Archives. Daniel Nathans Collection
Rights:
Reproduced with permission of Joanne Nathans.
Subject:
Medical Subject Headings (MeSH):
DNA Fragmentation
Exhibit Category:
New Directions: Growth Signals and Cellular Responses, 1980-1999
Relation:
Metadata Record Letter from Antonio M. Persico to Daniel Nathans (January 10, 1992) pdf (106,413 Bytes) transcript of pdf
/ps/access/PDBBGK.pdf
Unique Identifier:
PDBBGJ
Document Type:
Letters (correspondence)
Language:
English
Format:
application/pdf
image/tif
Physical Condition:
Good
Transcript:
1/15/92
Dear Dr. Persico:
I looked up the Zerial et al. paper on FosB and Nakabeppu's data here. We have no reason to say FosB mRNA is 5 kb. We were quoting Zerial et al. in our paper. Further, Zerial et al. have no reason to say it is 5 kb. They had an incomplete cDNA of 4145 nucleotides and speculated that it might have another 1 kb. Since they didn't map the 5' end of the mRNA, they can't know how much is missing from the 5' end. Therefore the mRNA could be 4.2 kb (or if their unusually long 5' cDNA segment is partly artifactual, even smaller).
The main thing for your purposes is that the mRNA you identify has the same mobility as the one they identified. There is no reason to doubt that the probe is FosB and that the signal is due to FosB mRNA.
Sincerely,
Daniel Nathans
Metadata Last Modified Date:
2009-12-18
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