Skip to main contentU.S. National Library of MedicineU.S. National Library of Medicine

Profiles in Science
Pinterest badge Follow Profiles in Science on Pinterest!

The Sol Spiegelman Papers

Letter from Roy H. Doi to Sol Spiegelman pdf (68,320 Bytes) transcript of pdf
Letter from Roy H. Doi to Sol Spiegelman
Number of Image Pages:
1 (68,320 Bytes)
1965-07-01 (July 1, 1965)
Doi, Roy H.
University of California, Davis
Spiegelman, Sol
Reproduced with permission of Roy H. Doi.
Medical Subject Headings (MeSH):
RNA, Ribosomal
Exhibit Category:
RNA-DNA Hybridization in Viruses, 1955-1965
Metadata Record Letter from Sol Spiegelman to Roy H. Doi (July 26, 1965) pdf (93,716 Bytes) transcript of pdf
Box Number: 3
Folder Number: 1
Unique Identifier:
Document Type:
Letters (correspondence)
Physical Condition:
Series: Correspondence, 1946-1983
Folder: Doi, Roy H., 1959-1970
July 1, 1965
Dear Sol:
Greetings from God's country! After a long journey across the country we have finally settled down a bit. My lab is still in the process of getting organized, but within two weeks our work should be proceeding at its usual rate.
There is one question that I would like to ask. In your studies on hybrid formation between ribosomal RNA and DNA, you found that B. megaterium R-RNA did not hybridize with E. coli DNA. In our studies with B. subtilis R-RNA we are finding that it will hybridize with E. coli and Prot. vulgaris DNA when assayed by the Hall-Spiegelman SWB method and the Nygaard-Hall membrane method. However, B. subtilis R-RNA does not hybridize with Ps. aeruginosa DNA under any condition. Did you ever try hybridizing your megaterium R-RNA with any other specie(s)? We are finding some very interesting results with interspecies hybridization particularly with R-RNA. The M-RNA has not been conserved among Bacillus species according to our results.
Also I would appreciate receiving a couple more reprints of the paper in the Regulation Symposium at Marseilles, if still available. Thank you.
Since we are building a home, I hope you will be able to visit us sometime in the near future. I hope you will let me know when you visit the West Coast in order that I may set up a visit for you.
With best regards,
Sincerely yours,
Roy H. Doi
Metadata Last Modified Date:
Linked Data:
RDF/XML     JSON     JSON-LD     N3/Turtle     N-Triples