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The Sol Spiegelman Papers

Letter from Joshua Lederberg to Sol Spiegelman pdf (62,000 Bytes) transcript of pdf
Letter from Joshua Lederberg to Sol Spiegelman
Number of Image Pages:
1 (62,000 Bytes)
1948-05-20 (May 20, 1948)
Lederberg, Joshua
Spiegelman, Sol
This item is in the public domain. It may be used without permission.
Exhibit Category:
Enzymes and Genetics, 1940-1955
Metadata Record Letter from Sol Spiegelman to Joshua Lederberg (May 25, 1948) pdf (85,051 Bytes) transcript of pdf
Box Number: 6
Folder Number: 42
Unique Identifier:
Document Type:
Letters (correspondence)
Physical Condition:
Series: Correspondence, 1946-1983
Folder: Lederberg, Joshua, 1946-1978
May 20, 1948.
Dear Sol,
Winge's reprints just arrived, and I've had the pleasure of reading them, I don't think you have much to quarrel about with him, at least in the ultimate interpretations, although one may wonder whether you will agree with him in regard to even the long-term adaptability of your mel- strains. Do you confirm his observations on galactose-fermentation by S. Bayanus? When it comes down to it, in his G x gs crosses, he is demonstrating the transmission of the cytoplasmic mechanism for long-term adaptation. Of course this is a "phenotypic" phenomenon -- so is your melibiose story. It seems to me that it is this issue which differentiates your viewpoint from Lindegren's, since he has been talking about changes of the locus, and you do not. In Winge's material, perhaps the most interesting experiment has not been done, namely on the effect of preadaptation of the G parent on the rate of adaptation of the gs segregants of a G x gs cross, or even a gs(adapted) x gs(nonadapted).
But the purpose of this letter is not to reconcile you with Winge, which it's none of my business to do, but to remind you please to send me a copy of the first crude draft of the writeup of the pink yeast work, as soon as convenient.
When are you leaving St. Louis -- via the CSH meetings?
Best regards,
Joshua Lederberg
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