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The Sol Spiegelman Papers

Title:
Letter from Joshua Lederberg to Sol Spiegelman pdf (83,963 Bytes) transcript of pdf
Letter from Joshua Lederberg to Sol Spiegelman
Number of Image Pages:
2 (83,963 Bytes)
Date:
1948-02-11 (February 11, 1948)
Creator:
Lederberg, Joshua
Recipient:
[Spiegelman, Sol]
Rights:
This item is in the public domain. It may be used without permission.
Subject:
Medical Subject Headings (MeSH):
Yeasts
Enzymes
Exhibit Category:
Enzymes and Genetics, 1940-1955
Relation:
Metadata Record Letter from Sol Spiegelman to Joshua Lederberg (February 16, 1948) pdf (48,345 Bytes) transcript of pdf
/ps/access/PXBBFZ.pdf
Box Number: 6
Folder Number: 42
Unique Identifier:
PXBBGB
Document Type:
Letters (correspondence)
Language:
English
Format:
application/pdf
image/tif
Physical Condition:
Good
Series: Correspondence, 1946-1983
Folder: Lederberg, Joshua, 1946-1978
Transcript:
February 11, 1948.
Dear Sol-
Would you be kind enough to send me some yeast strains that I may need for my work? My requirements are of two types:
Firstly, I need some differential fermenters for a microbiological assay of enzyme-lactose mixtures, as a check on other methods. If you have strains with the following properties, I would appreciate transfers:
[chart]
Secondly, I am getting a very bewildering picture on the genetic control of lactose-enzymes in E. coli. There are several loci mutation of which leads, specifically, to lac-; on the otherhand, there are a number of mutations which block simultaneously the utilization of a few sugars, with no rhyme or reason apparent as yet. E.g. maltose-, lactose-, gluconate- (but glucose, galactose, pentose plus)! I would be interested to look sometime for similar bewilderment in yeast. The genetic tests would be much easier, since one need examine only the diploid heterozygote to get a good line on allelism. You say that EMB works with yeast. Would you care to send two opposite mating type, dispersely growing haploids that I could use for mutation-production? I'll send you whatever comes out, of course. As for producing them, I've got that down to a T-- and have accumulated, for example, about 50 independent occurrences of Lac-mutations in coli.
Have you and Reiner formulated your next-year's plans yet?
Best regards,
Joshua
[chart]
Metadata Last Modified Date:
2008-07-25
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