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The Sol Spiegelman Papers

Title:
Letter from Martin R. Pollock to Sol Spiegelman pdf (82,404 Bytes) transcript of pdf
Letter from Martin R. Pollock to Sol Spiegelman
Number of Image Pages:
1 (82,404 Bytes)
Date:
1951-10-16 (October 16, 1951)
Creator:
Pollock, Martin R.
Medical Research Council. National Institute for Medical Research
Recipient:
Spiegelman, Sol
Rights:
Reproduced with permission of the National Institute for Medical Research.
Subject:
Medical Subject Headings (MeSH):
Penicillinase
Enzymes
Exhibit Category:
RNA-DNA Hybridization in Viruses, 1955-1965
Relation:
Metadata Record Letter from Sol Spiegelman to Martin R. Pollock (October 1, 1951) pdf (114,759 Bytes) transcript of pdf
/ps/access/PXBBGZ.pdf
Metadata Record Letter from Sol Spiegelman to Martin R. Pollock (October 19, 1951) pdf (95,921 Bytes) transcript of pdf
/ps/access/PXBBGX.pdf
Box Number: 9
Folder Number: 29
Unique Identifier:
PXBBGY
Document Type:
Letters (correspondence)
Language:
English
Format:
application/pdf
image/tif
Physical Condition:
Good
Series: Correspondence, 1946-1983
Folder: Pollock, Martin, 1946-1966
Transcript:
16th October, 1951.
Dear Spiegelman,
Many thanks for your letter of the 1st October. Since writing to you I have, of course, seen the recent issue of the Proc. Nat. Acad. Sci. containing your last article. Many thanks also for all the information you gave, which is very interesting. I should like sometime to know if you have any scheme for visualizing how your discrete particles, which are apparently inherited through the cytoplasm, actually function in promoting enzyme synthesis.
As far as our own work goes, you have presumably seen my last paper on penicillinase adaptation, since I sent you a reprint. We have since followed that up by investigating the absorption of penicillin sulphur on to the cells, using the same pretreatment technique as for adaptation experiments, by means of S35-labelled penicillin. We have found that there is a pretty close correlation between the amount of penicillin sulphur specifically fixed on the cells and the effect of penicillin in stimulating subsequent production of penicillinase in a penicillin-free medium, following pretreatment at 0 degrees plus thorough washing of cells. In this particular case at least, there seems to be fairly good evidence that some sort of specific interaction between penicillin and a specific penicillin receptor within the cells is first necessary in order for the cells to adapt to penicillinase formation. It is interesting that the amounts of penicillinase sulphur firmly fixed on the cells are exceedingly small - maximal adaptation effect being achieved after the fixation of about 100 S per cell.
Do you yet know whether you will be coming to the Biochemical Congress in Paris next year?
With best wishes,
Yours sincerely,
M. R. Pollock.
Metadata Last Modified Date:
2010-07-19
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