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The Sol Spiegelman Papers

Title:
Letter from Martin R. Pollock to Sol Spiegelman pdf (88,116 Bytes) transcript of pdf
Letter from Martin R. Pollock to Sol Spiegelman
Description:
Item is handwritten.
Number of Image Pages:
2 (88,116 Bytes)
Date:
1947-03-18 (March 18, 1947)
Creator:
Pollock, Martin R.
Medical Research Council. The Lister Institute
Recipient:
Spiegelman, Sol
Rights:
Reproduced with permission of the National Institute for Medical Research.
Exhibit Category:
Enzymes and Genetics, 1940-1955
Relation:
Metadata Record Letter from Sol Spiegelman to Martin R. Pollock (April 7, 1947) pdf (142,313 Bytes) transcript of pdf
/ps/access/PXBBHD.pdf
Box Number: 9
Folder Number: 29
Unique Identifier:
PXBBHF
Document Type:
Letters (correspondence)
Language:
English
Format:
application/pdf
image/tif
Physical Condition:
Good
Series: Correspondence, 1946-1983
Folder: Pollock, Martin, 1946-1966
Transcript:
March 18 1947
Dear Dr Spiegelman,
Thank you very much for your letter of March 12 which I was very glad to get. I [ . . . ] the [ . . . ] you work[?] for. I am very pleased you enjoyed the Nibenam[?] papers and would like to discuss the points you raise in detail but I don't really think this can be done satisfactorily in a letter, and I am much looking forward to meeting you some time during your visit here. The mannitol [?] v. formata [ . . . ] is to a large extent a mystery because although I quite [ . . . ] these coli will grow on mannitol [?] and nor[?] formata as sole[?] C source, I don't think anybody has any clear ideas why. What, for instance, do you mean by "sufficient energy source"? Formate will [ . . . ] O2 in insulate[?] in the [ . . . ] of [ . . . ] more rapidly than mannitol [?], therefore in one server[?] formata is a [ . . . ] sufficient energy source[?] than mannitol [?] (or glucose). One is rather forced to the conclusion that formata cannot be synthesized into [ . . . ] essential higher C compound, which mannitol[?] can. But I admit is might be, or you suggest, a protein[?] y energy relationships if you make the hypothesis that the energy from formata [ . . . ] cannot [ . . . ] be utilized by the cells at all, or at least not for the [ . . . ] of protein synthesis!
The point you raise about the [ . . . ] [ . . . ] [ . . . ] protein is interesting. I cannot say definitely that the [ . . . ] is not acting on a [ . . . ] of assimilable[?] N, though I think it unlikely; but
[END PAGE ONE]
[BEGIN PAGE TWO]
I did not got into this point in detail and I can think of further experiments better planned to test your point that the ones I did or [ . . . ] times[?]. I comes[?] hardly accept the difference of [ . . . ][ . . . ] in Table 7 of 50 to 17 or evidence of mannitol [?] enzyme [ . . . ] since it worked the other way around with [ . . . ]! (the column 6[?]) You will, I think, be interested to hear that [ . . . ] recently, in the [ . . . ]systematic search for subatomic[?] promoting [ . . . ] [ . . . ] in the protein[?] of an [ . . . ] N [ . . . ] (but before the beginning of cell growth) I have found that certain [ . . . ] a [ . . . ] have a ray pronounced [ . . . ] effect. The work is [ . . . ] [ . . . ] in the early stages and I do not like to draw hasty conclusions, but the [ . . . ] to nucleic acid[?] nucleoprotein synthesis is obvious. If this time proves [ . . . ] I hope to bring it up at the Copenhagen Congress in July.
Please let me know approximately when you will be in this country as I am much looking forward to meeting you.
Yours sincerely
M.R. Pollack
P.S. Is Sereg[?] taken seriously in the U.S.? I have just been reading the "adaptive enzyme" section of his review in the latest "Advances in Enzymology. I think this action has [ . . . ] a number of people here and I must confess I feel rather annoyed myself. His objections, though superficially ingenious, do not bear shouting[?]; he is inconsistent and often illogical, he ignores work that does not fit in with his own ideas and ends wit ha perfectly shattering misquotation from Maxinie[?]Staplman's[?] paper on the adaptation of forensic[?] hydrogengase[?]. The way he dismisses [ . . . ] [ . . . ] wit ha wave of his hand in quick [ . . . ] and he does not even [ . . . ] own work or [ . . . ] in an otherwise [ . . . ] and respectable journal. I should be interested to know how he is held and what influence he has in the States.
M.R.P.
Metadata Last Modified Date:
2010-08-25
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