Letter from Rudolph J. Anderson to Florence R. Sabin
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1927-12-22 (December 22, 1927)
Anderson, Rudolph J.
Sabin, Florence R.
Original Repository: American Philosophical Society. Library. Florence R. Sabin Papers
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At the Rockefeller Institute for Medical Research, 1925-1938
Anderson, Rudolph J., #14
Dear Dr. Sabin,
I am very interested in the results mentioned in your letter of the 16th and they seem very significant. But apparently you
will have to study general fats as well as our particular fatty acid. As a beginning in this direction I would suggest that
you study the effect of simple substances, oleic acid for instance, rather than complex glycerides containing numerous unknown
substances, such as olive oil.
I agree with you that smaller doses and fewer doses of the saturated fatty acid should be given. I should also advise that
several animals be given these doses and that you determine their fate when left to themselves. How long would it take for
the breakdown of the tubercular tissue and what would happen to the animal when such breakdown begins?
To begin with I will send you a lot of the purified wax, some more of the saturated fatty acid and also some oleic acid. I
shall send directions as to dosage and methods of administration.
Another thing I would like to ask you--Do you think that the fatty material in the artificial tuberculosis tissue would cause
a similar development if introduced into another normal animal? Would normal rabbit fat introduced into a healthy rabbit produce
a similar abnormal development? If normal rabbit fat should be inert this might prove a good method of introducing foreign
fats--that is dissolving the foreign fat in the rabbit fat and then injecting it.
It would seem as if you have a large problem before you and it will take some time to work it out. I feel immensely interested
in the effect of the saturated fatty acid. But is this a specific effect or will other fats give similar results? Please try
some oleic acid in comparison to begin with.
With the best greetings,
R. J. Anderson
[P.S.] As to fat from normal rabbits--do you have any or could you have some prepared at the Institute? If you have none and
can't get any prepared conveniently, but if you would be interested in trying it I shall try to prepare some for you here.