Letter from Florence R. Sabin to Rudolph J. Anderson
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1929-10-04 (October 4, 1929)
Sabin, Florence R.
Anderson, Rudolph J.
Original Repository: American Philosophical Society. Library. Florence R. Sabin Papers
Reproduced with permission of Geraldine F. Swan.
Medical Subject Headings (MeSH):
At the Rockefeller Institute for Medical Research, 1925-1938
Letter from Rudolph J. Anderson to Florence R. Sabin (October 5, 1929)
Anderson, Rudolph J., #11
October 4, 1929.
My dear Dr. Anderson,
I have just been working on our records of the avian stain and they are as follows.
The Avian phosphatid gave the same reaction as the human phosphatid after twelve doses but not quite as massive. The lesions
were in part in the form of tubercle-like bodies, more in the diffuse reaction of epitheliod cells. The epithelioid cell
was the predominating reaction and there were large numbers of the typical epithelioid or Langhans giant cells.
The Evian fatty acid on the other hand gave a reaction much more like that from the glycerides than like Fatty acid I from
the human phosphatid A-3. In one animal R 922 there was a consider irritation of the serosal lining cells and a few leucocytes
free in the tissues. Epithelioid cells were present in small numbers and the more striking thing was the presence of large
numbers of foreign body giant cells. In the second animal R 923, both having received 12 intraperitoneal injections of 20
mgm in 0.5cc nujol, there were many more epithelioid cells but all of them scattered; none in the form of tubercles. Again
the most striking reaction was of foreign body giant cells. This is interesting since it was the reaction of the Fatty acid
IV from the glycerides which was relatively less optically active. We do not know at all the reason for the formation of
the foreign body giant cells in these reactions but they are not the form especially characteristic of tuberculosis lesions.
The sections of the bovine material have not yet been finished but I had them started the moment that your letter came and
they will be ready Monday or Tuesday at the latest. We have learned not to analyze our data until we get the sections too
for sometimes there are things in them that we misses in the fresh. I will study them and send you the report Tuesday or
Wednesday of next week; will that be in time.
We too are struggling and we shall say the same as you if we ever get through.