In this lecture Crick provided an account of genetic experiments conducted with Leslie Barnett, Sydney Brenner, and Richard
Watts-Tobin in 1961. In these experiments they used acridine mutants of viral DNA (mutants produced by chemicals of the acridine
type, such as proflavin, which trigger additions to or deletions from the base sequence) in order to demonstrate that the
genetic code was a three-letter code. They published their findings in a seminal article in Nature in December 1961, entitled
"General Nature of the Genetic Code for Proteins."
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Original Repository: Wellcome Library for the History and Understanding of Medicine. Francis Harry Compton Crick Papers