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The Francis Crick Papers

Title:
Letter from Francis Crick to Robert L. Sinsheimer pdf (55,983 Bytes) transcript of pdf
Letter from Francis Crick to Robert L. Sinsheimer
Description:
In this letter Crick refers to genetic experiments undertaken with Leslie Barnett, Sydney Brenner, and Richard Watts-Tobin on acridine mutants, which indicated that the genetic code was a triplet code. Compelling evidence that poly-U (a synthetic form of RNA consisting of bases of a single type, uracil) coded for the amino acid phenylalanine was first presented by the American biochemist Marshall Nirenberg in the summer of 1961.
Number of Image Pages:
1 (55,983 Bytes)
Date:
1961-10-09 (October 9, 1961)
Creator:
Crick, Francis
Recipient:
Sinsheimer, Robert L.
Source:
Original Repository: Wellcome Library for the History and Understanding of Medicine. Francis Harry Compton Crick Papers
URL: http://archives.wellcome.ac.uk/Exit
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Rights:
Reproduced with permission of the Wellcome Library for the History and Understanding of Medicine.
URL: http://library.wellcome.ac.uk/Exit
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Subject:
Medical Subject Headings (MeSH):
Genetic Code
Exhibit Category:
Deciphering the Genetic Code, 1958-1966
Box Number: 32
Folder Number: PP/CRI/E/1/10/4/3
Unique Identifier:
SCBBCQ
Document Type:
Letters (correspondence)
Language:
English
Format:
application/pdf
image/tif
Physical Condition:
Good
Series: Travels and Meetings
SubSeries: Meetings Attended
SubSubSeries: Travels and Meetings 1962
SubSubSubSeries: "US 1962"
Folder: Biophysical Society Meeting, Washington DC
Transcript:
9th October, 1961.
Dear Bob,
Many thanks for your letter and the further invitation. I would be most reluctant to come west in February because I have to be in San Francisco from about 9th to 1lth or so of April, and could perhaps manage to come to give a colloquium at Cal.Tech. after that and just before I go home. Would that be a suitable time?
We now have convincing genetic evidence that the coding ratio is 3 or a multiple of 3. It is not clear that we can prove that it is 3 rather than 6, but we are trying. I will send you a copy of a manuscript as soon as we have one. Jim Ofengand has also confirmed, in a preliminary way, that poly U makes polyphenalamine.
With best wishes,
F. H. C. Crick.
Metadata Last Modified Date:
2008-10-07
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