Skip to main contentU.S. National Library of MedicineU.S. National Library of Medicine


Profiles in Science
   
Pinterest badge Follow Profiles in Science on Pinterest!

The Francis Crick Papers

Title:
On Degenerate Templates and the Adaptor Hypothesis: A Note for the RNA Tie Club pdf (1,584,862 Bytes) ocr (34,904 Bytes)
On Degenerate Templates and the Adaptor Hypothesis: A Note for the RNA Tie Club
Description:
In this, one of the most important unpublished articles in the history of science, Crick predicted the existence of adaptor molecules and enzymes for each of the twenty common amino acids. These adaptors, which were in fact found shortly thereafter and were later named transfer RNA, were essential in assembling amino acids into the polypeptide chains of which proteins consist. Moreover, Crick here introduced the concept of a "degenerate" genetic code, meaning a code in which more than one combination of DNA bases could specify a particular amino acid, as was later shown to be the case.
The RNA Tie Club was a group of twenty molecular biologists (one for each amino acid) chosen by the physicist and cosmologist George Gamow in 1953 to stimulate the exchange of ideas about the nature of the genetic code.
Number of Image Pages:
18 (1,584,862 Bytes)
Date:
1955
Creator:
Crick, Francis
Source:
Original Repository: Wellcome Library for the History and Understanding of Medicine. Francis Harry Compton Crick Papers
URL: http://archives.wellcome.ac.uk/Exit
   Disclaimer; please review our Privacy Policy
Rights:
Reproduced with permission of the Wellcome Library for the History and Understanding of Medicine.
URL: http://library.wellcome.ac.uk/Exit
   Disclaimer; please review our Privacy Policy
Subject:
Medical Subject Headings (MeSH):
Genetic Code
RNA
Exhibit Category:
Defining the Genetic Coding Problem, 1954-1957
Relation:
Metadata Record Letter from James D. Watson to Francis Crick (February 10, 1955) pdf (442,568 Bytes) transcript of pdf
/ps/access/SCBBJL.pdf
Box Number: 72
Folder Number: PP/CRI/H/1/38
Unique Identifier:
SCBBGF
Document Type:
Articles
Language:
English
Format:
application/pdf
image/tif
Physical Condition:
Good
Series: Notes and Drafts
SubSeries: Notes and Drafts 1950-1955
Folder: "On degenerate templates and the adaptor hypothesis"
Metadata Last Modified Date:
2004-12-20
Linked Data:
RDF/XML     JSON     JSON-LD     N3/Turtle     N-Triples