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The Francis Crick Papers

Letter from H. Gobind Khorana to Francis Crick pdf (64,227 Bytes) transcript of pdf
Letter from H. Gobind Khorana to Francis Crick
In this letter Khorana conveyed some of the results of his work on phenylalanine tRNA in yeast and on repeating sequences of GUA, the codon for the amino acid valine.
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1 (64,227 Bytes)
1967-01-03 (January 3, 1967)
Khorana, H. Gobind
Crick, Francis
Original Repository: Wellcome Library for the History and Understanding of Medicine. Francis Harry Compton Crick Papers
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Reproduced with permission of H. Gobind Khorana.
Medical Subject Headings (MeSH):
Genetic Code
Exhibit Category:
Embryology and the Organization of DNA in Higher Organisms, 1966-1976
Metadata Record Letter from Francis Crick to H. Gobind Khorana (January 9, 1967) pdf (215,326 Bytes) transcript of pdf
Box Number: 9
Folder Number: PP/CRI/D/1/1/11
Unique Identifier:
Document Type:
Letters (correspondence)
Physical Condition:
Series: Correspondence
SubSeries: Alphabetical Correspondence
SubSubSeries: Correspondence 1
Folder: Correspondence K
January 3, 1967
Dear Francis:
Thanks for your letters of December 15th and 22nd.
I am now planning to come out to La Jolla for a few days. I shall probably be there from the 1st to the 4th of February.* I shall also write to Les and Ed Lennox, who is my point of contact at the moment, to see if C. Yanofsky can also come out there during those days.
The work on phenylalanine tRNA (yeast) is now finished and we are writing up a summary of the total work for publication. There is no modification in the structure except for deletion of one base (C) (7th from acceptor end) that I told you about last October. We are also writing up work on initiation codons as studied with repeating polymers. Poly GUA also seems to recognize f-met at low Mg++. At high Mg++ the polymer incorporates ser and val, as you know, but at 0.004 M we get valine incorporation only and this is dependent on addition of f-met. This stimulation, however, is low (5-fold over the background); at 0.01 M Mg++ valine incorporation, in the absence or presence of f-met, is about 140-150 fold, so the recognition is weak.
Sincerely yours,
H. Gobind Khorana
*arriving there on Jan 31st.
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