In this letter Kornberg laid out plans for a visit to Crick's laboratory, and reported further results of studies with
DNA polymerase, an enzyme that catalyses the formation of strands of DNA, which Kornberg had been using in experiments on
DNA replication since the late 1950s.
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1969-07-03 (July 3, 1969)
Original Repository: Wellcome Library for the History and Understanding of Medicine. Francis Harry Compton Crick Papers
My sabbatical leave has begun. I have an office in a quiet, out-of-the-way basement room in the chemistry building. It's
delightful. I will read and then make some measurements in molecular spectroscopy. I want also to become more familiar with
membrane structure especially as studied by spectroscopic and other physical methods.
Around January 1, my wife and I plan to start an 8-month period of travel. We would go west making southern Pacific stopovers
and perhaps a visit to E. Africa. This would bring us to Europe early in March and we would welcome an opportunity to settle
in Cambridge for about 2-3 months to visit laboratories engaged in membrane work. I'd like to look in on your lab, too,
if possible. We would also plan brief visits to laboratories in Paris, Gottingen, Utrecht and possibly others in Gothenburg
I would be grateful for your suggestions of the best time for coming to Cambridge and for housing. Since there are just two
of us and I have a rather generous Guggenheim grant this may not be a problem at all.
DNA polymerase does a dandy job in excising pyrimidine dimer lesions by its 5'-->3' exonuclease function. The
enzyme, by its replicative nick translation coupled with this "endonucleolytic" excision of mismatched sequences,
may be a candidate for the in vivo job.