Skip to main contentU.S. National Library of MedicineU.S. National Library of Medicine

Profiles in Science
Pinterest badge Follow Profiles in Science on Pinterest!

The Francis Crick Papers

Letter from Francis Crick to Sewell Champe pdf (84,949 Bytes) transcript of pdf
Letter from Francis Crick to Sewell Champe
Crick here briefly touched on research with acridine mutants of bacteriophage T4, experiments that demonstrated that the triplet UGA did not have a transfer RNA assigned to it, meaning that it coded not for an amino acid but for the end of the polypeptide chain in protein synthesis.
NOTE: The right margin of the orginal letter cuts off a portion of the text.
Number of Image Pages:
1 (84,949 Bytes)
1966-11-02 (November 2, 1966)
Crick, Francis
Champe, Sewell
Original Repository: Wellcome Library for the History and Understanding of Medicine. Francis Harry Compton Crick Papers
   Disclaimer; please review our Privacy Policy
Reproduced with permission of the Wellcome Library for the History and Understanding of Medicine.
   Disclaimer; please review our Privacy Policy
Medical Subject Headings (MeSH):
Genetic Code
Exhibit Category:
Embryology and the Organization of DNA in Higher Organisms, 1966-1976
Metadata Record Letter from Sewell Champe to Francis Crick (March 1, 1967) pdf (152,502 Bytes) transcript of pdf
Box Number: 8
Folder Number: PP/CRI/D/1/1/3
Unique Identifier:
Document Type:
Letters (correspondence)
Physical Condition:
Series: Correspondence
SubSeries: Alphabetical Correspondence
SubSubSeries: Correspondence 1
Folder: Correspondence C
2nd November 1966.
Dear Sewell,
I enclose a copy of our paper. From its weight alone you can see why it has taken us so long to produce it. I think I need only make two comments at this point. First, we have not said anything in it about the anomalous mapping of FC 58 we thought we could put this in proof when things are a little clearer. Second, we have removed from our earlier draft some of our remarks about the identity of the barriers as we plan to publish this in a separate paper. It now seems almost certain that X655 together with barriers b5 and b6 are UGA, and we hope to know very shortly whether b2 is the same. We are also going to try to put an amber in place of barrier b6 and see if this will produce minutes when combined with two suitable plus mutants. If it does not this will suggest that the production of minutes does not depend on chain termination. Our present case is that there is no tRNA for UGA.
How are you getting on in your search for the rII protein?
F.H.C. Crick.
Metadata Last Modified Date:
Linked Data:
RDF/XML     JSON     JSON-LD     N3/Turtle     N-Triples