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The Francis Crick Papers

Letter from Francis Crick to Paul Doty pdf (138,765 Bytes) transcript of pdf
Letter from Francis Crick to Paul Doty
In his letter Crick relayed information on the base sequence for transfer RNA for valine, as well as his "latest blast" against Watson's manuscript for The Double Helix.
GTP stands for guanosine triphosphate, a precursor in the synthesis of ribonucleic acid.
Number of Image Pages:
2 (138,765 Bytes)
1967-04-17 (April 17, 1967)
Crick, Francis
Doty, Paul
Original Repository: Wellcome Library for the History and Understanding of Medicine. Francis Harry Compton Crick Papers
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Reproduced with permission of the Wellcome Library for the History and Understanding of Medicine.
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Medical Subject Headings (MeSH):
Genetic Code
Exhibit Category:
Embryology and the Organization of DNA in Higher Organisms, 1966-1976
Box Number: 8
Folder Number: PP/CRI/D/1/1/4
Unique Identifier:
Document Type:
Letters (correspondence)
Physical Condition:
Series: Correspondence
SubSeries: Alphabetical Correspondence
SubSubSeries: Correspondence 1
Folder: Correspondence D
17th April 1967.
Dear Paul,
I enclose a copy of the valine sRNA sequence, together with some notes that you left behind. The most obvious suggestion that was made here was that the effect of GTP might be due to release of sRNA that was cluttering up the peptide site. To check this Thach should preincubate the ribosomes with GTP, then remove as much GTP as possible, and repeat his experiment in the presence of the inhibitor. If the above suggestion is correct the GTP should only be needed in the preincubation stage and not in the incubation proper to get the usual effect. Your notes which you wrote on the board have fortunately not been rubbed out and read as follows:-
Effect on freezing of phasing
20 degrees or 30 degrees
10 x sRNA
two step release
degradation of F met val phe
I am not quite sure what all these mean but I expect they will remind you of something.
Don't forget you were going to send me a copy of that review explaining how women are too fond of sex, and are restrained by the conventions of society.
I also enclose my latest blast against Jim. Bragg is beginning to wobble and I think now is the time for your and John Edsall to take a new look at the whole problem.
It was nice seeing you. Do come again any time you feel like it.
F.H.C. Crick.
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