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The Francis Crick Papers

Title:
Letter from Francis Crick to Joshua Lederberg pdf (86,769 Bytes) transcript of pdf
Letter from Francis Crick to Joshua Lederberg
Number of Image Pages:
1 (86,769 Bytes)
Date:
1965-04-02 (April 2, 1965)
Creator:
Crick, Francis
Recipient:
Lederberg, Joshua
Source:
Original Repository: Wellcome Library for the History and Understanding of Medicine. Francis Harry Compton Crick Papers
URL: http://archives.wellcome.ac.uk/Exit
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Rights:
Reproduced with permission of the Wellcome Library for the History and Understanding of Medicine.
URL: http://library.wellcome.ac.uk/Exit
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Exhibit Category:
Deciphering the Genetic Code, 1958-1966
Relation:
Metadata Record Letter from Joshua Lederberg to Francis Crick (March 24, 1965) pdf (120,704 Bytes) transcript of pdf
/ps/access/SCBBRX.pdf
Box Number: 10
Folder Number: PP/CRI/D/1/1/12
Unique Identifier:
SCBBRW
Document Type:
Letters (correspondence)
Language:
English
Format:
application/pdf
image/tif
Physical Condition:
Good
Series: Correspondence
SubSeries: Alphabetical Correspondence
SubSubSeries: Correspondence 1
Folder: Correspondence L
Transcript:
2nd April, 1965.
Dear Josh,
I have not yet seen Holley's paper in Science, but I think I follow most of what you say.
It is an old speculation that the S-RNA is so big because it may have to make a rather nicely balanced configurational change. However, it was assumed that this would come about when the amino acid was added. Your idea that it will only happen when the S-RIA combines with the correct codon is new to me.
I don't feel that there is anything hard to explain about the "Bernfield-Nirenberg" binding. You only have to assume that in addition to the binding energy between the codon and the anti-codon there is a weak general binding of S-RNA and codon to the ribosomes. I suspect that the binding between the codon and the anti-codon without the ribosome is too weak to be observable at all easily.
Basically I think your idea a good one, but it may be hard to prove it.
F. H. C. Crick
Metadata Last Modified Date:
2008-10-20
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