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The Francis Crick Papers

Title:
Letter from Francis Crick to Joshua Lederberg pdf (78,198 Bytes) transcript of pdf
Letter from Francis Crick to Joshua Lederberg
Number of Image Pages:
1 (78,198 Bytes)
Date:
1959-01-07 (January 7, 1959)
Creator:
Crick, Francis
Recipient:
Lederberg, Joshua
Source:
Original Repository: Wellcome Library for the History and Understanding of Medicine. Francis Harry Compton Crick Papers
URL: http://archives.wellcome.ac.uk/Exit
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Rights:
Reproduced with permission of the Wellcome Library for the History and Understanding of Medicine.
URL: http://library.wellcome.ac.uk/Exit
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Exhibit Category:
Deciphering the Genetic Code, 1958-1966
Relation:
Metadata Record Letter from Joshua Lederberg to Francis Crick (December 10, 1958) pdf (851,099 Bytes) transcript of pdf
/ps/access/SCBBRZ.pdf
Box Number: 10
Folder Number: PP/CRI/D/1/1/12
Unique Identifier:
SCBBRY
Document Type:
Letters (correspondence)
Language:
English
Format:
application/pdf
image/tif
Physical Condition:
Good
Series: Correspondence
SubSeries: Alphabetical Correspondence
SubSubSeries: Correspondence 1
Folder: Correspondence L
Transcript:
7 January 1959
Dear Josh,
The point Tamm raised - in as far as I understand it from your letter - is a valid one, but not a new one. It is usually expressed by saying that the triplet code only works for one chain of the DNA. It runs into difficulties if you do not know, by some other means, which chain to read (of course you must read one chain up and the other one down).
It is possible to write down a code so that all the reverse triplets on the other chain are nonsense. An example is:
[DNA TRIPLET CODES]
with the pairing rule A with D, B with C
for example the sense triplet BCA
has on the other chain CBD
but this must be read backwards, namely as DBC; which, as you can see, is not in the original set of triplets. This is true for all of them. Unfortunately, however, you can get a sense triplet on the reverse chain where two of these nonsense triplets overlap.
There are various ways round this but none is convincing. Perhaps we might discuss them in July.
Metadata Last Modified Date:
2010-11-17
Linked Data:
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