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The Francis Crick Papers

Letter from Francis Crick to Jacques Monod pdf (171,160 Bytes) transcript of pdf
Letter from Francis Crick to Jacques Monod
Number of Image Pages:
2 (171,160 Bytes)
1967-04-13 (April 13, 1967)
Crick, Francis
Monod, Jacques
Original Repository: Wellcome Library for the History and Understanding of Medicine. Francis Harry Compton Crick Papers
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Reproduced with permission of the Wellcome Library for the History and Understanding of Medicine.
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Exhibit Category:
Embryology and the Organization of DNA in Higher Organisms, 1966-1976
Box Number: 24
Folder Number: PP/CRI/D/2/26
Unique Identifier:
Document Type:
Letters (correspondence)
Physical Condition:
Series: Correspondence
SubSeries: Individual Correspondents
Folder: Correspondence: Monod, Jacques
13th April 1967.
Dear Jacques,
I have just had a letter from Danny Lehrman reminding us that we said we would visit his laboratory when we are both over there in October. I am still keen to do this. Are you? If so I think we should try to arrange a time otherwise it may turn out that the two of us cannot go on the same day. The obvious days are either Tuesday 17th October or Saturday 2lst October. As far as I am concerned the latter would be preferable providing Saturday is a possible day for Lehrman. Let me know what you feel. I expect Sydney will also come, but as he is in the States at the moment I cannot ask him which day is better for him.
There has been no change in our plans for Greece this year. We expect to go out about the middle of June and stay there till the end of July, although I have heard very little from the man who is looking after the boat and the engines. I think the most sensible idea would be to try to meet at a port in the middle of the Aegean soon after you have left Spetsai. It might be sensible if we fixed on a particular port and the approximate date, although I think we should have some other means of keeping in touch in case we miss each other. Which port do you think would be best for our rendezvous? I seem to remember you suggested Ios.
Sydney and the others have some suggestive evidence that UGA produces polypeptide chain termination. In brief, they have a strong suppressor which is specific for UGA and using this have converted two ochre mutants in B-galactosidase into UGA and shown that they have the same polar properties as do the ochre and amber at the same sites. Zipser has done something similar. However, we still lack direct evidence that UGA chain terminates, and because it is suppressed so easily we still think that UAA is the triplet commonly used for chain termination.
I have made some progress on the problem of why proteins aggregate using dyads. It is more complicated than I expected, but at least I can see the reasons in a general way. Probably the best time to talk about this would be when we meet in the summer.
F.H.C. Crick.
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