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The Francis Crick Papers

Title:
Central Dogma of Molecular Biology pdf (383,891 Bytes) ocr (12,539 Bytes)
Central Dogma of Molecular Biology
Description:
In this article Crick explained how his theory regarding the flow of genetic information in the cell, which he had introduced in 1957 as the "Central dogma" of molecular biology, was well able to accommodate recent findings by Howard Temin and David Baltimore that certain oncogenic RNA viruses direct synthesis of DNA in virus-infected cells, a process that came to be called reverse transcription. Contrary to the misconceptions of critics, Crick had not ruled out this form of residue-by-residue transfer of sequence information from RNA to DNA, although he expected it to be rare. (Indeed, it had not been shown to occur in cells other than those infected by viruses.) Moreover, the centerpiece of his theory, that sequential information used to synthesize proteins could not again flow out of proteins, was unaffected by Temin's findings.
Item is a photocopy.
Number of Image Pages:
3 (383,891 Bytes)
Date:
1970-08-08 (August 8, 1970)
Creator:
Crick, Francis
Source:
Periodical: Crick, Francis. "Central Dogma of Molecular Biology." Nature 227, (8 August 1970): 561-563. Article. 3 Images.
Publisher:
Nature Publishing Group
Rights:
Reproduced with permission of the Nature Publishing Group.
URL: http://www.nature.com/nature/index.htmlExit
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Exhibit Category:
Embryology and the Organization of DNA in Higher Organisms, 1966-1976
Unique Identifier:
SCBCCH
Document Type:
Articles
Language:
English
Format:
application/pdf
image/tif
Physical Condition:
Good
Folder: [Selected articles collected by NLM]
Metadata Last Modified Date:
2009-02-09
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