In this article Crick explained how his theory regarding the flow of genetic information in the cell, which he had introduced
in 1957 as the "Central dogma" of molecular biology, was well able to accommodate recent findings by Howard Temin
and David Baltimore that certain oncogenic RNA viruses direct synthesis of DNA in virus-infected cells, a process that came
to be called reverse transcription. Contrary to the misconceptions of critics, Crick had not ruled out this form of residue-by-residue
transfer of sequence information from RNA to DNA, although he expected it to be rare. (Indeed, it had not been shown to occur
in cells other than those infected by viruses.) Moreover, the centerpiece of his theory, that sequential information used
to synthesize proteins could not again flow out of proteins, was unaffected by Temin's findings.
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1970-08-08 (August 8, 1970)
Periodical: Crick, Francis. "Central Dogma of Molecular Biology." Nature 227, (8 August 1970): 561-563. Article. 3 Images.
Nature Publishing Group
Reproduced with permission of the Nature Publishing Group.