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The Francis Crick Papers

Title:
General Model for the Chromosomes of Higher Organisms pdf (555,419 Bytes) ocr (18,872 Bytes)
General Model for the Chromosomes of Higher Organisms
Description:
Crick here proposed a general model for the structure of chromosomes in higher eukaryotic cells. His model was designed to account for discoveries made during the 1960s that most of the DNA in higher organisms did not code for proteins but carried out genetic control functions, and that chromosomal DNA was most often associated with proteins, mainly histones, rather than in its pure double-helical form. Crick's model posited that chromosomal DNA consisted of "bands" of highly folded, unpaired single-stranded segments of double-stranded DNA, which carried out control functions. In between these stretches of "globular" DNA were much shorter stretches of "fibrous" DNA, similarly unpaired and single-stranded but extended and not folded, which coded for proteins.
Item is a photocopy.
Number of Image Pages:
3 (555,419 Bytes)
Date:
1971-11-05 (November 5, 1971)
Creator:
Crick, Francis
Source:
Periodical: Crick, Francis. "General Model for the Chromosomes of Higher Organisms." Nature 234, (5 November 1971): 25-27. Article. 3 Images.
Publisher:
Nature Publishing Group
Rights:
Reproduced with permission of the Nature Publishing Group.
URL: http://www.nature.com/nature/index.htmlExit
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Exhibit Category:
Embryology and the Organization of DNA in Higher Organisms, 1966-1976
Unique Identifier:
SCBCCM
Document Type:
Articles
Language:
English
Format:
application/pdf
image/tif
Physical Condition:
Good
Folder: [Selected articles collected by NLM]
Metadata Last Modified Date:
2009-02-09
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