General Model for the Chromosomes of Higher Organisms
Crick here proposed a general model for the structure of chromosomes in higher eukaryotic cells. His model was designed to
account for discoveries made during the 1960s that most of the DNA in higher organisms did not code for proteins but carried
out genetic control functions, and that chromosomal DNA was most often associated with proteins, mainly histones, rather than
in its pure double-helical form. Crick's model posited that chromosomal DNA consisted of "bands" of highly folded,
unpaired single-stranded segments of double-stranded DNA, which carried out control functions. In between these stretches
of "globular" DNA were much shorter stretches of "fibrous" DNA, similarly unpaired and single-stranded but
extended and not folded, which coded for proteins.
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1971-11-05 (November 5, 1971)
Periodical: Crick, Francis. "General Model for the Chromosomes of Higher Organisms." Nature 234, (5 November 1971): 25-27. Article.
Nature Publishing Group
Reproduced with permission of the Nature Publishing Group.