This study sought to explain the apparent role of calcium ions in muscle contraction, by searching for a component of muscle
tissue that would have an affinity for Ca ions. Reasoning that such material would probably have a structure that included
negative groups such as sulfites, and knowing that such molecules were often "metachromatic" (i.e., would stain to
a different color than that of the dye applied to them), Szent-Gyorgyi tested various muscle components--myosin, actomyosin,
and other fractions--for their ability to turn toluidine blue (a lab stain) purple. He extracted a metachromatic protein and
called it "metin."
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1963-12-15 (December 15, 1963)
Periodical: Szent-Gyorgyi, Albert, and B. Kaminer. "Metin and Metactomyosin." Proceedings of the National Academy of Sciences
of the United States of America 50, 6 (15 December 1963): 1033-1036. Article. 4 Images.
National Academy of Sciences (U.S.)
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