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The Arthur Kornberg Papers

Title:
Letter from Carl F. Cori to Arthur Kornberg pdf (39,910 Bytes) transcript of pdf
Letter from Carl F. Cori to Arthur Kornberg
Description:
Kornberg's former mentor Carl Cori wrote to suggest another possible interpretation of a reaction involving TPN, and added a postscript saying, "What mysterious creatures enzymes are."
Number of Image Pages:
1 (39,910 Bytes)
Date:
1951-02-15 (February 15, 1951)
Creator:
Cori, Carl F.
Washington University School of Medicine
Recipient:
Kornberg, Arthur
Source:
Original Repository: Stanford University Libraries. Department of Special Collections and University Archives. Arthur Kornberg Papers
Rights:
Reproduced with permission of the Washington University School of Medicine.
Subject:
Medical Subject Headings (MeSH):
Enzymes
Exhibit Category:
From Physician to Enzyme Hunter, 1942-1953
Box Number:
15
Unique Identifier:
WHBBBX
Document Type:
Letters (correspondence)
Language:
English
Format:
application/pdf
image/tif
Physical Condition:
Good
Transcript:
February 15, 1951
Dear Arthur:
I read your abstract in Fed. Proc. 1950 again, after Gerty told me about your interest in the adenylic effect on the DPN specific "isocitric dehydrogenase" in yeast. You have undoubtedly considered this, but for my own information, could isocitric be decarboxylated first, leaving A-hydroxyglutaric acid, followed by dehydrogenation over DPN. In other words, have you tried A-hydroxyglutaric acid + DPN <=> A-ketoglutaric acid + DPNM to the right (or to the left, if equilibrium not too unfavorable).
Best regards,
Sincerely,
Carl F. Cori
P.S. Adenylic could act by "laying on of hands;" at least, that is what we say about its action on phosphorylase. What mysterious creatures enzymes are.
Metadata Last Modified Date:
2008-12-15
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