Kornberg's former mentor Carl Cori wrote to suggest another possible interpretation of a reaction involving TPN, and added
a postscript saying, "What mysterious creatures enzymes are."
Number of Image Pages:
1 (39,910 Bytes)
1951-02-15 (February 15, 1951)
Cori, Carl F.
Washington University School of Medicine
Original Repository: Stanford University Libraries. Department of Special Collections and University Archives. Arthur Kornberg Papers
Reproduced with permission of the Washington University School of Medicine.
Medical Subject Headings (MeSH):
From Physician to Enzyme Hunter, 1942-1953
February 15, 1951
I read your abstract in Fed. Proc. 1950 again, after Gerty told me about your interest in the adenylic effect on the DPN specific
"isocitric dehydrogenase" in yeast. You have undoubtedly considered this, but for my own information, could isocitric
be decarboxylated first, leaving A-hydroxyglutaric acid, followed by dehydrogenation over DPN. In other words, have you tried
A-hydroxyglutaric acid + DPN <=> A-ketoglutaric acid + DPNM to the right (or to the left, if equilibrium not too unfavorable).
Carl F. Cori
P.S. Adenylic could act by "laying on of hands;" at least, that is what we say about its action on phosphorylase.
What mysterious creatures enzymes are.