Skip to main contentU.S. National Library of MedicineU.S. National Library of Medicine


Profiles in Science
   
Pinterest badge Follow Profiles in Science on Pinterest!

The Arthur Kornberg Papers

Title:
Letter from Arthur Kornberg to G. David Novelli pdf (43,088 Bytes) transcript of pdf
Letter from Arthur Kornberg to G. David Novelli
Description:
In this letter, Kornberg responded to biochemist G. David Novelli's letter describing the activity of an enzyme Kornberg had sent him.
Number of Image Pages:
1 (43,088 Bytes)
Date:
1950-11-14 (November 14, 1950)
Creator:
Kornberg, Arthur
Recipient:
Novelli, G. David
Massachusetts General Hospital
Source:
Original Repository: Stanford University Libraries. Department of Special Collections and University Archives. Arthur Kornberg Papers
Rights:
Reproduced with permission of Arthur Kornberg.
Subject:
Medical Subject Headings (MeSH):
Enzymes
Exhibit Category:
From Physician to Enzyme Hunter, 1942-1953
Relation:
Metadata Record Letter from G. David Novelli to Arthur Kornberg (November 6, 1950) pdf (111,487 Bytes) transcript of pdf
/ps/access/WHBBCG.pdf
Box Number:
15
Unique Identifier:
WHBBCH
Document Type:
Letters (correspondence)
Language:
English
Format:
application/pdf
image/tif
Physical Condition:
Good
Transcript:
November 14, 1950
Dear Dave:
As you must know, I was very much interested in the information in your letter. It begins to look as if the structure of Co A is being clarified rapidly.
I am very disappointed that the preparation we sent you had DPN splitting activity of 900 units/ml.; I am sure it started out at 2700 units/ml. If the phosphatase contaminant in this preparation did not go down in activity--and it probably did not--then it approaches a significant nuisance level. In our work with TPN splitting, we were careful not to prolong the reaction beyond the time necessary to split TPN. Or the phosphate liberation was always negligible.
In paper chromatography of adenine nucleotides, ADP can be separated from the mononucleotide (as reported in a recent J. Am. Chem. Soc. by Carter and Cohn), but I cannot tell you what the relative behavior is of the "ADP" of TPN origin.
I would be very happy to have you come down whenever it is convenient. As a formality, it may be desirable for Doctor Lipmann to write a letter to the Director, but I am certain this will involve no difficulty at all.
With best regards to you and Doctor Lipmann from all of us,
Sincerely yours,
Arthur Kornberg
Metadata Last Modified Date:
2008-11-10
Linked Data:
RDF/XML     JSON     JSON-LD     N3/Turtle     N-Triples