Original Repository: Stanford University Libraries. Department of Special Collections and University Archives. Arthur Kornberg Papers
Reproduced with permission of Arthur Kornberg.
Medical Subject Headings (MeSH):
"Creating Life in the Test Tube," 1959-1970
Letter from H. George Mandel to Arthur Kornberg (January 7, 1960)
January 11, 1960
Thanks for writing and telling me about your interesting experiments. I can only guess at the interpretation but would favor
The question of "turnover" of DNA or of DNA synthesis in the absence of cell division can be debated but I'm inclined
to feel that it's safer to assume it can occur. After all, when the cells are presented with a variety of confusing environmental
factors they may try to initiate "growth" even though some of the essential factors eventually prove to be limiting.
I imagine some of Zamenhof's experience with bromouracil incorporation (described in a recent JBC) has some points of
similarity to yours.