In their work with DNA polymerase, Kornberg and his colleagues had found that it could induce a seemingly spontaneous synthesis
of an adenine-thymine polymer, without a template. This phenomenon raised a number of questions about the nature of chemical
bonds in nucleotides and nucleic acids, and the exact mechanism of the polymerase. In this letter, Henry Sobell asked Kornberg
about the feasibility of approaching some of these problems via crystallographic studies and included his research proposal
on this topic.
Number of Image Pages:
1 (41,083 Bytes)
1964-12-31 (December 31, 1964)
Sobell, Henry M.
Massachusetts Institute of Technology
Original Repository: Stanford University Libraries. Department of Special Collections and University Archives. Arthur Kornberg Papers
Reproduced with permission of Henry M. Sobell.
"Creating Life in the Test Tube," 1959-1970
Letter from Arthur Kornberg to Henry M. Sobell (April 22, 1965)
December 31, 1964
Dear Dr. Kornberg:
There have been several important developments in the field of purine-pyrimidine cocrystallization during this past year which
I thought would be of special interest to you. In particular, there is a possibility that a correlation exists between the
de novo synthesis of the perfectly alternating dAT copolymer and the Hoogsteen pairing configuration found in the adenine-thymine
crystalline complexes. I have therefore taken the liberty of sending you a copy of my research proposal which describes this
in considerable detail.
I would greatly appreciate your comments about this.