Assay in Man of the Chemical Fractions of Veratrum Viride, and Identification of the Pure Alkaloids Germitrine and Germidine
as Potent Hypotensive Principles Derived from the Drug
Veratrum viride was a common herbal remedy for high blood pressure. By the late 1940s, it was widely recognized as a useful
antihypertensive agent, however it unfortunately produced side effects such as violent retching, nausea, and vomiting. Freis
and several of his colleagues at various Boston hospitals attempted to separate the active antihypertensive components of
the drug from its emetic effects. In this article, they reported that they had successfully extracted two previously undiscovered
active alkaloids (germitrine and germidine) that lowered blood pressure without the deleterious side effects.
Number of Image Pages:
8 (760,002 Bytes)
1950-02 (February 1950)
Freis, Edward D.
Stanton, Joseph R.
Moister, F. Corbin
Periodical: Freis, Edward D., Joseph R. Stanton, and F. Corbin Moister. "Assay in Man of the Chemical Fractions of Veratrum Viride,
and Identification of the Pure Alkaloids Germitrine and Germidine as Potent Hypotensive Principles Derived from the Drug."
Journal of Pharmacology and Experimental Therapeutics 98, 2 (February 1950): 166-173. Article. 8 Images.
[Williams & Wilkins]
This item is in the public domain. It may be used without permission.
Medical Subject Headings (MeSH):
Early Career and Work with Antihypertensive Drugs, 1940-1949