Captopril: Evaluation of Low Doses, Twice-Daily Doses and the Addition of Diuretic for the Treatment of Mild to Moderate Hypertension
In the early 1980s, a new class of drugs were developed that treated hypertension by preventing the synthesis of certain hormones
that caused blood vessels to constrict. These drugs, of which Captopril was one, were designated as angiotensin converting
enzyme (ACE) inhibitors. Freis's team reported that Captopril, which up to then had only been administered to the most
severe hypertensive patients, effectively reduced blood pressure in lower doses than indicated in previous studies, reducing
the likelihood of deleterious side effects. As a result, they recommended that its use be extended to the general population.
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Veterans Administration Cooperative Study Group on Antihypertensive Agents
Periodical: Veterans Administration Cooperative Study Group on Antihypertensive Agents. "Captopril: Evaluation of Low Doses, Twice-Daily
Doses and the Addition of Diuretic for the Treatment of Mild to Moderate Hypertension." Clinical Science 63, (1982): 443s-445s.
Article. 3 Images.
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Medical Subject Headings (MeSH):
After 1980: Changing Trends in Hypertension Therapy