Evaluation of Toxicity in Long-Term Clinical Trials
Along with being a pioneer in hypertension treatment, Freis was a pioneer in the evolution of controlled double-blind clinical
trials. In this article, he argued that patients in clinical trials must be protected from hazards by prior trials in animals
and acute trials in patients, as well as effective design, careful observation, and prompt reporting of toxicity.
Number of Image Pages:
4 (684,021 Bytes)
1964-02-01 (February 1, 1964)
Freis, Edward D.
Periodical: Freis, Edward D. "Evaluation of Toxicity in Long-Term Clinical Trials." Journal of the American Medical Association
187, 5 (1 February 1964): 352-355. Article. 4 Images.
American Medical Association
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Medical Subject Headings (MeSH):
Drug-Related Side Effects and Adverse Reactions
Clinical Trials as Topic
The Veterans Administration Hospital and Georgetown University School of Medicine, 1949-1964