Throughout the 1980s, Freis felt compelled to defend the use of diuretics for use as an antihypertensive agent. Some researchers
believed that diuretic-induced hypokalemia might bring about fatal arrhythmias, others felt that long-term use encouraged
high cholesterol, and thus posed a risk of coronary artery disease. In this article, Freis and Papademetriou concluded that
the accumulated evidence does not support the conclusion that thiazide diuretics increased cardiovascular risk.
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Freis, Edward D.
Periodical: Freis, Edward D., and Vasilios Papademetriou. "How Dangerous Are Diuretics?" Drugs 30, 6 (1985): 469-474. Article.
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Medical Subject Headings (MeSH):
After 1980: Changing Trends in Hypertension Therapy