Relationship Between Plasma and Extracellular Fluid Volume Depletion and the Antihypertensive Effect of Chlorothiazide
Freis and Wilson collaborated on several papers on various treatments for hypertension in the 1950s. In this article, they
discussed the effect of the diuretic chlorothiazide on extracellular fluid and plasma, noting that it significantly reduced
both plasma volume and body weight during the first two to three days of treatment. They noted, however, that continued use
resulted in no further reduction of extracellular fluid.
Number of Image Pages:
9 (1,081,294 Bytes)
1959-12 (December 1959)
Wilson, Ilse M.
Freis, Edward D.
Periodical: Wilson, Ilse M., and Edward D. Freis. "Relationship Between Plasma and Extracellular Fluid Volume Depletion and the Antihypertensive
Effect of Chlorothiazide." Circulation XX, 6 (December 1959): 1028-1036. Article. 9 Images.
[American Heart Association]
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Medical Subject Headings (MeSH):
The Veterans Administration Hospital and Georgetown University School of Medicine, 1949-1964
Mechanism of the Antihypertensive Effects of Diuretics: Possible Role of Salt in Hypertension [May-June 1960]