Treatment of Essential Hypertension with Chlorothiazide (Diuril): Its Use Alone and Combined with Other Antihypertensive Agents
In this article, Freis and his colleagues reported the results of their initial trials of the new diuretic, chlorothiazide,
in patients with moderate hypertension. Chlorothiazide often reduced blood pressure when used alone; when used together with
other antihypertensive drugs, it potentiated their effects, so that lower doses of the other drugs could be used, and side-effects
could be avoided. Chlorothiazide represented a major advance in the treatment of hypertension.
Number of Image Pages:
4 (581,708 Bytes)
1958-01-11 (January 11, 1958)
Freis, Edward D.
Wilson, Ilse M.
Parrish, Alvin E.
Periodical: Freis, Edward D., Annemarie Wanko, Ilse M. Wilson, and Alvin E. Parrish. "Treatment of Essential Hypertension with Chlorothiazide
(Diuril): Its Use Alone and Combined with Other Antihypertensive Agents." Journal of the American Medical Association
166, 2 (11 January 1958): 137-140. Article. 4 Images.
American Medical Association
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The Veterans Administration Hospital and Georgetown University School of Medicine, 1949-1964