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The Edward D. Freis Papers

Title:
Comparison of Propranolol and Hydrochlorothiazide for the Initial Treatment of Hypertension: I. Results of Short-Term Titration with Emphasis on Racial Differences in Response pdf (1,631,708 Bytes) ocr (45,025 Bytes)
Comparison of Propranolol and Hydrochlorothiazide for the Initial Treatment of Hypertension: I. Results of Short-Term Titration with Emphasis on Racial Differences in Response
Description:
Propranolol, a beta-adrenergic antagonist (beta-blocker), was developed in the 1960s. By slowing the heart rate and pumping volume, it also lowers blood pressure, and so was used to control hypertension. By the late 1970s a few experts had suggested that propranolol, effective and well-tolerated by many patients, might replace thiazide diuretics as the first step in hypertension treatment. In this article Freis and his colleagues report on a clinical trial that compared the two drugs. They found that they worked equally well in white patients, but that the diuretic hydrochlorothiazide worked better in African-American patients. They recommended that treatment continue to be based on assessment of the individual patient, and that it include a consideration of medication costs; propranolol could cost more than 20 times as much for equivalent doses as hydrochlorothiazide.
NOTE: This was the best scan that could be obtained (photocopy is of poor quality).
Item is a photocopy.
Number of Image Pages:
8 (1,631,708 Bytes)
Date Supplied:
22/29 October 1982
Creator:
Veterans Administration Cooperative Study Group on Antihypertensive Agents
Source:
Periodical: Veterans Administration Cooperative Study Group on Antihypertensive Agents. "Comparison of Propranolol and Hydrochlorothiazide for the Initial Treatment of Hypertension: I. Results of Short-Term Titration with Emphasis on Racial Differences in Response." Journal of the American Medical Association 248, 16 ([22/29 October 1982]): 1996-2003. Article. 8 Images.
Publisher:
[American Medical Association]
Rights:
This item is in the public domain. It may be used without permission.
Subject:
Medical Subject Headings (MeSH):
Hypertension
Antihypertensive Agents
Hydrochlorothiazide
Propranolol
Exhibit Category:
After 1980: Changing Trends in Hypertension Therapy
Relation:
Metadata Record Comparison of Propranolol and Hydrochlorothiazide for the Initial Treatment of Hypertension: II. Results of Long-Term Therapy [22/29 October 1982] pdf (1,582,137 Bytes) ocr (50,519 Bytes)
/ps/access/XFBBDP.pdf
Box Number: 7
Folder Number: 12
Unique Identifier:
XFBBLX
Document Type:
Articles
Language:
English
Format:
application/pdf
image/tif
Physical Condition:
Good
Series: Writings and Lectures, 1942-2002
SubSeries: Articles and Essays, 1942-2001
Folder: Col - Com, 1943-86
Metadata Last Modified Date:
2007-01-12
Linked Data:
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