Title:

Program in Molecular Neurobiology Proposal

Creator:

Lederberg, Joshua

Date:

30 August 1962

Location:

Box: 5. Folder: 35

Rights:

Public Domain

Genre:

Grant proposals

Format:

Text

Extent:

7 pages

Language:

English

Legacy ID:

BBGLBX

NLM ID:

101584906X18441

Profiles Collection:

The Joshua Lederberg Papers

Shareable Link:

https://profiles.nlm.nih.gov/101584906X18441

Annotation:

Author: Joshua Lederberg. Date Written: January 26, 2004. KW: This was to have been the centerpiece of the programs sponsored by the Kennedy Laboratories for Molecular Medicine; it was funded; I am seeking more detail about progress reports, and its gradual devolution to Eric Shooter's studies on NGF - Nerve Growth Factor; it would be called "Brain Proteomics" today, and that study still needs to be implemented, along with comprehensive quests for genetic polymorphisms; The microscan mass spectrometer is an anticipation of MALDI; alas our vacuum systems were too clean, and we missed others' inadvertent discoveries of matrix assistance. Episequential prtotein modification: has been vindicated in many other examples of post-translational modification, e.g methylation of histones; hunch about glutamine is probably flawed, but ...,; N.B.: cf realiation of this strategy in: AU COMINGS, DE TI PC1 DUARTE, A COMMON POLYMORPHISM OF A HUMAN-BRAIN PROTEIN, AND ITS RELATIONSHIP TO DEPRESSIVE DISEASE AND MULTIPLE-SCLEROSIS SO NATURE VL 277: 28 - 32 ; 1979 C1 CITY HOPE NATL MED CTR,DEPT MED GENET,DUARTE,CA 91010 --- Of course, colorblindness must be an instance; further note 1/26/04: posttranslational deamidation is reported for cytochrome see CEN 2/17/02 Flatmark jl 10/29/02 8/04/03 1/26/04

Lederberg Grouping:

NONE. No Epoch.