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An important early piece of correspondence between the two scientists on what would eventually be the basis for their Nobel Prize-winning research, i.e., sexual recombination in bacteria. The letter embodies Lederberg's proposal to Tatum to search for such genetic recombination. The letter was written by Lederberg from Columbia College of Physicians and Surgeons where he was a medical student in the last months of the Navy V-12 program, the war (World War II) having ended only weeks before.