Title:

Letter from Joshua Lederberg to Louis Dienes

Creator:

Lederberg, Joshua

Recipient:

Dienes, Louis R.

Date:

9 October 1946

Location:

Box: 6. Folder: 10

Rights:

Public Domain

Genre:

Letters (correspondence)

Subject:

Mutation and Genetics, Microbial

Format:

Text

Extent:

1 pages

Language:

English

Legacy ID:

BBAACQ

NLM ID:

101584906X67

Profiles Collection:

The Joshua Lederberg Papers

Shareable Link:

https://profiles.nlm.nih.gov/101584906X67

Annotation:

Author: Joshua Lederberg. Date Written: April 18, 1999. Node: Dienes, Louis. Microbiologist at MGH, long preoccupied with morphological studies of "L-forms" (Large bodies?); cf also Klieneberger-Nobel; These and their "filtrability" were all to obvious options for a morphological correlate of sexuality, or later of the filtrable agent (FA) in transduction that later proved to be phage. Merry chase!; Now esp. after P-70. generally accepted as protoplasts or spheroplasts - they are indeed fusible in eukaryotes and gram-positive bacteria. L-forms no longer susceptible to wall-targeted antibiotics, perhaps also complement, may play a role in cryptic infections. Mellon had called similar things "zygospores". oI don't know what he finally made of the wall-defect story. KW: L-forms; Proteus; Carl Beam; chloral hydrate; swarm; ?? mechanism; cf phenol. jl 7/5/98; 4/18/99

Lederberg Grouping:

CA. Correspondence A.