Title:

The Nutrition of Salmonella

Creator:

Lederberg, Joshua

Date:

May 1947

Periodical:

Archives of Biochemistry

Publisher:

The Academic Press

Location:

Box: 79. Folder: 13

Rights:

Reproduced with permission of the Academic Press., http://www.elsevierdirect.com/imprint.jsp?iid=5, and Single copies of the article can be downloaded and printed for the reader's personal research and study.

Genre:

Articles

Subject:

Salmonella, Nutritional Physiological Phenomena, Genetics, Microbial, and Mutation

Format:

Text

Extent:

4 pages

Relation:

Letter from Joshua Lederberg to M. C. Nesheim, 1996

Language:

English

Legacy Source Citation:

Periodical. Lederberg, Joshua. "The Nutrition of Salmonella." Archives of Biochemistry 13, 2 (May 1947): 287-290. Article. 4 Images.. Archives of Biochemistry. Lederberg UI. P8

Legacy ID:

BBABEQ

NLM ID:

101584906X773

Profiles Collection:

The Joshua Lederberg Papers

Shareable Link:

https://profiles.nlm.nih.gov/101584906X773

Annotation:

Author: Joshua Lederberg. Date Written: February 28, 1999. KW: Salmonella auxotrophs; work started from the start of my studies at YALE (from April 1946 on), reflecting earliest convictions that serotypes in Salmonella bore earmarks of genetic recombination in natuiral history. Natural auxotrophs would also offer easy experimental material for\crossing studies, perhaps obviating need to seek laboratory mutants. The footnote makes it clear that I was already headed towards a Ph.D. credential by Feb '47. Most Salmonellas were auxo-autotrophic; tryptophane and cystine were common among the auxoheterotrophic forms . The natural historical or ecological significance remains obscure. Probably too little attention is paid to the accumulation of metabolically significant intermediates in the blocked strains. [cf also dmesiology or self-restraint!; but there has been no test of the impact on virulence of the natural auxotrophies.] Reversions were readily noted. Latent genes, raw material for divergent evolution, are also discussed here.\ jl 1/15/99

Lederberg Grouping:

P. Published Scientific Article.