Title:

The Soluble Specific Substance of Pneumococcus

Creator:

Heidelberger, Michael
Avery, Oswald Theodore, 1877-1955

Date:

June 1923

Description:

Avery's research on the specific soluble substance, or SSS, was an attempt to identify the substance that was responsible for the specific immunological reactions produced in pneumonia patients. Here, Avery and Heidelberger detailed their efforts to obtain pure samples of SSS and hypothesized that the substance consisted primarily of carbohydrates, rather than a protein, which was then believed to be the only substance that could stimulate antibody production. This article was published six years after an article written with Alphonse Dochez on SSS. The collaboration between Avery and Heidelberger initiated a line of research that yielded two articles, and after Heidelberger left for Mount Sinai Hospital in 1924, several by Avery with Walther Goebel and F.H. Babers in the late 1920s.

Periodical:

Journal of Experimental Medicine

Publisher:

Rockefeller University. Press

Rights:

Reproduced from The Journal of Experimental Medicine, 1923, vol. 38, pp. 73-79 by copyright permission of The Rockefeller University Press.

Genre:

Articles

Format:

Text

Extent:

7 pages

Relation:

The Elaboration of Specific Soluble Substance by Pneumococcus During Growth, 1917
Immunologic Relationships of Cell Constituents of Pneumococcus, 1923
The Soluble Specific Substance of Pneumococcus: Second Paper, 1924
The Soluble Specific Substance of Pneumococcus: Third Paper, 1925
The Soluble Specific Substance of Pneumococcus: IV. On the Nature of the Specific Polysaccharide of Type III Pneumococcus, 1926
The Soluble Specific Substance of Pneumococcus: V. On the Chemical Nature of the Aldobionic Acid from the Specific Polysaccharide of Type III Pneumococcus, 1927

Language:

English

Legacy Source Citation:

Periodical. Heidelberger, Michael, and Oswald T. Avery. "The Soluble Specific Substance of Pneumococcus." Journal of Experimental Medicine 38, 1 (June 1923): 73-79. Article. 7 Images.. Journal of Experimental Medicine

Legacy ID:

CCGMBS

NLM ID:

101584575X534

Profiles Collection:

The Oswald T. Avery Collection

Shareable Link:

https://profiles.nlm.nih.gov/101584575X534

Story Section:

The Making of an Immunologist: Heidelberger's Years at the Rockefeller Institute, 1912-1927