Chemo-Immunological Studies on Conjugated Carbohydrate-Proteins: IX. The Specificity of Antigens Prepared by Combining the p-Aminophenol Glycosides of Disaccharides with Protein
- Title:
- Chemo-Immunological Studies on Conjugated Carbohydrate-Proteins: IX. The Specificity of Antigens Prepared by Combining the p-Aminophenol Glycosides of Disaccharides with Protein
- Creator:
-
Avery, Oswald Theodore, 1877-1955
Babers, Frank H.
Goebel, Walther Friedrich, 1899-1993 - Date:
- November 1934
- Description:
- The ninth of a long series of studies on efforts by Avery's lab to chemically couple the type-II and type-III pneumonia polysaccharides to protein. Although Avery oversaw most of these experiments, their principle investigator was Goebel, who in 1939, independently demonstrated that the specificity of the type-III polysaccharide is inherent in the structure of the disaccharide, glucose-glucuronic acid. When the disaccharide was coupled with the protein, it yielded a synthetic antigen that induced the formation of antibodies reactive with the intact polysaccharide. These antibodies could protect laboratory animals against type-III infection.
- Periodical:
- Journal of Experimental Medicine
- Publisher:
- Rockefeller University. Press
- Rights:
- Reproduced from the Journal of Experimental Medicine, 1934, 60, 599-616, by copyright permission of the Rockefeller University Press.
- Genre:
- Articles
- Format:
- Text
- Extent:
- 18 pages
- Relation:
- Chemo-Immunological Studies on Conjugated Carbohydrate-Proteins: I. The Synthesis of p-Aminophenol beta-Glucoside, p-Aminophenol beta-Galactoside, and Their Coupling with Serum Globulin, 1929 Chemo-Immunological Studies on Conjugated Carbohydrate-Proteins: II. Immunological Specificity of Synthetic Sugar-Protein Antigens, 1929 Chemo-Immunological Studies on Conjugated Carbohydrate-Proteins: III. Active and Passive Anaphylaxis with Synthetic Sugar-Proteins, 1929 Chemo-Immunological Studies on Conjugated Carbohydrate-Proteins: IV. The Synthesis of the p-Aminobenzyl Ether of the Soluble Specific Substance of Type III Pneumococcus and Its Coupling with Protein, 1931 Chemo-Immunological Studies on Conjugated Carbohydrate-Proteins: V. The Immunological Specificity of an Antigen Prepared by Combining the Capsular Polysaccharide of Type III Pneumococcus with Foreign Protein, 1931 Chemo-Immunological Studies on Conjugated Carbohydrate-Proteins: VI. The Synthesis of p-Aminophenol alpha-Glucoside and Its Coupling with Protein, 1932 Chemo-Immunological Studies on Conjugated Carbohydrate-Proteins: VII. Immunological Specificity of Antigens Prepared by Combining alpha- and beta-Glucosides of Glucose with Proteins, 1932 Chemo-Immunological Studies on Conjugated Carbohydrate-Proteins: VIII. The Influence of the Acetyl Group on the Specificity of Hexoside-Protein Antigens, 1934
- Language:
- English
- Legacy Source Citation:
- Periodical. Goebel, Walther F., Oswald T. Avery, and Frank H. Babers. "Chemo-Immunological Studies on Conjugated Carbohydrate-Proteins: IX. The Specificity of Antigens Prepared by Combining the p-Aminophenol Glycosides of Disaccharides with Protein." Journal of Experimental Medicine 60, 5 (November 1934): 599-616. Article. 18 Images.. Journal of Experimental Medicine
- Legacy ID:
- CCGMCV
- NLM ID:
- 101584575X555
- Profiles Collection:
- The Oswald T. Avery Collection
- Shareable Link:
- https://profiles.nlm.nih.gov/101584575X555
- Story Section:
- Shifting Focus: Early Work on Bacterial Transformation, 1928-1940