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The Occurrence during Acute Infections of a Protein Not Normally Present in the Blood: II. Isolation and Properties of the Reactive Protein
- Title:
- The Occurrence during Acute Infections of a Protein Not Normally Present in the Blood: II. Isolation and Properties of the Reactive Protein
- Creator:
- Avery, Oswald Theodore, 1877-1955
MacLeod, Colin M. (Colin Munro), 1909-1972 - Date:
- February 1941
- Description:
- After detecting a new protein, the "C-reactive protein," in the serum of pneumonia patients, Avery and T. J. Abernethy set out to investigate what they believed to be an aspect of the infectious process that transcended the classic antigen-antibody reactions. Over the course of three papers in 1941, Avery and Abernethy, and later Avery and MacLeod, defined the characteristics of the protein and established that it was not an antibody. They cited evidence that the protein was instead released from tissue, likely as a result of cellular damage, and thus was a product of some nonspecific reaction of tissue to injury. Avery and MacLeod were further able to isolate the C-reactive protein as a highly purified, immunologically homogeneous protein.
- Periodical:
- Journal of Experimental Medicine
- Publisher:
- Rockefeller University. Press
- Rights:
- Reproduced from the Journal of Experimental Medicine, 1941, 73, 183-190, by copyright permission of the Rockefeller University Press.
- Genre:
- Articles
- Format:
- Text
- Extent:
- 8 pages
- Relation:
- The Occurrence during Acute Infections of a Protein Not Normally Present in the Blood: I. Distribution of the Reactive Protein in Patients' Sera and the Effect of Calcium on the Flocculation Reaction with C Polysaccharide of Pneumococcus, 1941 The Occurrence during Acute Infections of a Protein Not Normally Present in the Blood: III. Immunological Properties of the C-Reactive Protein and Its Differentiation from Normal Blood Proteins, 1941
- Language:
- English
- Legacy Source Citation:
- Periodical. MacLeod, Colin M., and Oswald T. Avery. "The Occurrence during Acute Infections of a Protein Not Normally Present in the Blood: II. Isolation and Properties of the Reactive Protein." Journal of Experimental Medicine 73, 2 (February 1941): 183-190. Article. 8 Images.. Journal of Experimental Medicine
- Legacy ID:
- CCGMCX
- NLM ID:
- 101584575X557
- Profiles Collection:
- The Oswald T. Avery Collection
- Shareable Link:
- https://profiles.nlm.nih.gov/101584575X557
- Story Section:
- DNA as the "Stuff of Genes": The Discovery of the Transforming Principle, 1940-1944