Studies on the Chemical Nature of the Substance Inducing Transformation of Pneumococcal Types: III. An Improved Method for the Isolation of the Transforming Substance and Its Application to Pneumococcus Types II, III, and VI

Title:
Studies on the Chemical Nature of the Substance Inducing Transformation of Pneumococcal Types: III. An Improved Method for the Isolation of the Transforming Substance and Its Application to Pneumococcus Types II, III, and VI
Creator:
Avery, Oswald Theodore, 1877-1955
McCarty, Maclyn
Date:
January 1946
Description:
In this second of two direct follow-ups to the 1944 paper on the Transforming Principle, Avery and McCarty provided further details of experimentation which showed that citrate (a salt or ester of citric acid) acted as a powerful inhibitor of enzymatic action on DNA, thus resulting in high yields of transforming DNA during experiments. Later, McCarty wrote that when one considered the combined data of the three papers, "there was not much room left for the skeptics to advance sensible alternatives to the view that DNA was the active substance in transformation."
Periodical:
Journal of Experimental Medicine
Publisher:
Rockefeller University. Press
Rights:
Reproduced from the Journal of Experimental Medicine, 1946, 83, 97-104, by copyright permission of the Rockefeller University Press.
Genre:
Articles
Format:
Text
Extent:
8 pages
Relation:
Letter from Oswald T. Avery to Roy Avery, 1943
Studies on the Chemical Nature of the Substance Inducing Transformation of Pneumococcal Types: Induction of Transformation by a Desoxyribonucleic Acid Fraction Isolated from Pneumococcus Type III, 1944
Studies on the Chemical Nature of the Substance Inducing Transformation of Pneumococcal Types: II. Effect of Desoxyribonuclease on the Biological Activity of the Transforming Substance, 1946
Language:
English
Legacy Source Citation:
Periodical. McCarty, Maclyn, and Oswald T. Avery. "Studies on the Chemical Nature of the Substance Inducing Transformation of Pneumococcal Types: III. An Improved Method for the Isolation of the Transforming Substance and Its Application to Pneumococcus Types II, III, and VI." Journal of Experimental Medicine 83, 2 (January 1946): 97-104. Article. 8 Images.. Journal of Experimental Medicine
Legacy ID:
CCGMDB
NLM ID:
101584575X560
Profiles Collection:
The Oswald T. Avery Collection
Shareable Link:
https://profiles.nlm.nih.gov/101584575X560
Story Section:
After the Discovery: The Transforming Principle's Reception by the Scientific Community