Title:

Chemotherapy of Trypanosome and Spirochete Infections: Chemical Series. I. N-Phenylglycineamide-p-Arsonic Acid

Creator:

Heidelberger, Michael
Jacobs, Walter A.

Date:

October 1919

Description:

Early twentieth-century scientists had long been attempting to treat trypanosomiasis, or African Sleeping Sickness, with arsenic-based compounds. Unfortunately, these compounds were largely ineffective and highly toxic. In light of this, Heidelberger and Walter Jacobs began work to formulate an alternate treatment for the disease. This article describes the pair's successful creation of a simple, non-toxic, and easily made arsenic compound to treat sleeping sickness, which Simon Flexner, director of the Rockefeller Institute, named "tryparasamide."

Periodical:

Journal of Experimental Medicine

Publisher:

Rockefeller Institute for Medical Research

Rights:

Public Domain

Genre:

Articles

Subject:

Drug Therapy and Spirochaetales

Format:

Text

Extent:

5 pages

Language:

English

Legacy Source Citation:

Periodical. Jacobs, Walter A., and Michael Heidelberger. "Chemotherapy of Trypanosome and Spirochete Infections: Chemical Series. I. N-Phenylglycineamide-p-Arsonic Acid." Journal of Experimental Medicine 30, 5 (October 1919): 411-415. Article. 5 Images.. Journal of Experimental Medicine

Legacy ID:

DHBBBB

NLM ID:

101584940X1

Profiles Collection:

The Michael Heidelberger Papers

Shareable Link:

https://profiles.nlm.nih.gov/101584940X1

Story Section:

The Making of an Immunologist: Heidelberger's Years at the Rockefeller Institute, 1912-1927