Quantitative Studies on the Precipitin Reaction: The Role of Multiple Reactive Groups in Antigen-Antibody Union as Illustrated by an Instance of Cross-Precipitation

Title:
Quantitative Studies on the Precipitin Reaction: The Role of Multiple Reactive Groups in Antigen-Antibody Union as Illustrated by an Instance of Cross-Precipitation
Creator:
Heidelberger, Michael
Kendall, Forrest E.
Date:
April 1934
Description:
In this article, Heidelberger and Kendall gave further evidence that antigens and antibodies were multivalent, meaning that there was more than one reactive group in each that allowed antigens and antibodies to form two (in the case of antibodies, as was later shown) or more (in the case of antigens) chemical bonds. This finding was crucial in understanding antigen-antibody reactions, and ran counter to the assertion by many scientists of the time, including the famous physical chemist Linus Pauling, that antibodies were univalent.
Periodical:
Journal of Experimental Medicine
Publisher:
Rockefeller Institute for Medical Research
Rights:
Reproduced from the Journal of Experimental Medicine, 1934, 59, 519-528 by copyright permission of the Rockefeller University Press.
Genre:
Articles
Subject:
Antigen-Antibody Reactions and Precipitins
Format:
Text
Extent:
10 pages
Language:
English
Legacy Source Citation:
Periodical. Heidelberger, Michael, and Forrest E. Kendall. "Quantitative Studies on the Precipitin Reaction: The Role of Multiple Reactive Groups in Antigen-Antibody Union as Illustrated by an Instance of Cross-Precipitation." Journal of Experimental Medicine 59, 4 (April 1934): 519-528. Article. 10 Images.. Journal of Experimental Medicine
Legacy ID:
DHBBBT
NLM ID:
101584940X16
Profiles Collection:
The Michael Heidelberger Papers
Shareable Link:
https://profiles.nlm.nih.gov/101584940X16
Story Section:
Antigens and Antibodies: Heidelberger and The Rise of Quantitative Immunochemistry, 1928-1954